组胚学英文版课件Digestive Tract.ppt

Colorectal Cancer is a malignant neoplasm of the colon or the rectum. Adenocarcinoma is the most common type of colon cancer (98% of cases. Presenting symptoms may be a change in bowel habits due to bowel obstruction, blood in the stool, or iron de?ciency anemia. This photomicrograph shows a moderately differentiated adenocarcinoma of the colon in?ltrating the muscularis propria. Crohn Disease a chronic autoimmune in?ammatory disease of the gastrointestinal tract that may affect any location, from the oral cavity to the anus, but mostly involves the distal small intestine and colon. This image shows colonic mucosa with depletion of goblet cells, noncaseating granulomas within the lamina propria, chronic in?amma-tion, and neutrophils invading the crypt cells. Comparative of different part of digestive tract Appendix Fewer and shorter intestinal glands and more lymph tissue Gastrointestinal associated lymphoid tissue (GALT) M: macrophage; MC: microfold; PC: plasma cell Endocrine cell Location：present between the epithelial lining and glands Types: Open、Closed Digestive Tract Review The general structure of digestive tract Histology of the esophagus The microstructure of stomach The small intestinal glands and microvillus * ii.??secret intrinsic factor- glycoprotein + VB12→absorption of VB12 a. chief cell or zymogenic cell ---structure: LM: columnar Round, basally-located Nucleus cytoplasm: /basal-basophilic /apical-zymogen granules EM: RER, Golgi apparatus ---function: secret pepsinogen c. mucous neck cell less, neck part columnar flattened, basally-located N pale stain in HE stain d. stem cell: undifferentiated cell e. endocrine cell ECL cell: secreting histamine, promote secretion of parietal cell D cell: secreting somatostatin, inhibit the secretion of parietal cell 1.chief cell 2.parietal cell 3.mucous neck cell ③ Muscularis mucosa: inner circular and outer longitudinal arranged SM 2)??submucosa: CT with BV