A novel study on amyloid β peptide 40, 42 and 4042 ratio in Saudi autistics.docVIP

Al-Ayadhietal.BehavioralandBrainFunctions2012,8:4 /content/8/1/4 RESEARCH OpenAccess Anovelstudyonamyloidbpeptide40,42and 40/42ratioinSaudiautistics LailaYAl-Ayadhi1,2,3,AbirGBenBacha2,3,4,MalakKotb4,5 andAfafKEl-Ansary2,3,4* Abstract Objectives:Weexaminedwhetherplasmaconcentrationsofamyloidbeta(Ab)asproteinderivativesplaya centralroleintheetiologyofautisticfeatures. DesignandMethods:ConcentrationsofhumanAb(1-42),Ab(1-40),andAb(40/42)intheplasmaof52autistic children(aged3-16years)and36age-matchedcontrolsubjectsweredeterminedbyusingtheELISAtechnique andwerecompared. Results:Comparedtocon