A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis.docVIP

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2017-05-15 发布于上海
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A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis.doc

A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis

Wallisetal.ArthritisResearchTherapy2011,13:R15 /content/13/1/R15 RESEARCH ARTICLE OpenAccess Apolymorphismintheinterleukin-4receptor affectstheabilityofinterleukin-4toregulate Th17cells:apossibleimmunoregulatory mechanismforgeneticcontroloftheseverity ofrheumatoidarthritis SusanKWallis,LauraACooney,JudithLEndres,MinJieLee,JenniferRyu,EmilyCSomers,DavidAFox* Abstract Introduction:Rheumatoidarthritis(RA)isnowsuspectedtobedrivenbypathogenicTh17cellsthatsecrete interleukin(IL)-17andcanberegulatedbyIL-4.Asingle-nucleotidepolymorphism(SNP),I50V,inthecodingregion ofthehumanIL-4receptor(IL-4R)isass

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A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis.docVIP