原创力文档A proteomic approach for the identification of novel lysine methyltransferase substrates.docVIP
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A proteomic approach for the identification of novel lysine methyltransferase substrates
Levyetal.EpigeneticsChromatin2011,4:19
/content/4/1/19
METHODOLOGY
OpenAccess
Aproteomicapproachfortheidentificationof
novellysinemethyltransferasesubstrates
DanLevy1*?,ChihLongLiu1,2?,ZeYang1,AaronMNewman3,4,AshAAlizadeh3,4,PaulJUtz2*andOrGozani1*
Abstract
Background:Signalingviaproteinlysinemethylationhasbeenproposedtoplayacentralroleintheregulationof
manyphysiologicandpathologicprograms.Incontrasttootherpost-translationalmodificationssuchas
phosphorylation,proteome-wideapproachestoinvestigatelysinemethylationnetworksdonotexist.
Results:Inthecurrentstudy,weusedtheProtoArray? platform,c
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