A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis.docVIP

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A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis.doc

A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

Cardieletal.ArthritisResearchTherapy2010,12:R192 /content/12/5/R192 RESEARCH ARTICLE OpenAccess Aphase2randomized,double-blindstudyof AMG108,afullyhumanmonoclonalantibodyto IL-1R,inpatientswithrheumatoidarthritis MarioHCardiel1*,PaulPTak2,WilliamBensen3,FrancisXBurch4,SarkaForejtova5,JanuszEBadurski6, TarundeepKakkar7,TerryBevirt8,LiyunNi9,EllenMcCroskery10,AngelikaJahreis10,DebraJZack10 Abstract Introduction:PreclinicalworkhassuggestedthatIL-1playsacriticalroleinthepathogenesisofrheumatoid arthritis(RA).Theobjectiveofthepresentstudywastodeterminetheeffectofalong-actingIL-1receptor inhibito

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A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis.docVIP