A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis.docVIP

van der Kraan et al. Arthritis Research Therapy 2010,12:201 /content/12/1/201 RE VIE W A role for age-related changes in TGFβ signaling in aberrant chondrocyte di? erentiation and osteoarthritis Peter M van der Kraan*, Esmeralda N Blaney Davidson and Wim B van den Berg trigger, while secondary OA is the result of an evident Abstract underlying a? iction. e main features of this disease are Transforming growth factor beta (TGFβ) is a growth factor with many faces. In our osteoarthritis (OA) research we have found that TGFβ can be protective as well as deleterious for articula