Addressing the challenges to successful recruitment and retention in Alzheimers disease clinical trials.docVIP

Grill and Karlawish Alzheimer’s Research Therapy 2010,2:34 /content/2/6/34 RE VIE W Addressing the challenges to successful recruitment and retention in Alzheimer’s disease clinical trials Joshua D Grill* and Jason Karlawish 1 2 After a review of the literature and experiences in AD clinical trial conduct, this paper summarizes the challenges related to AD trial recruitment and retention for phase II and phase III randomized, placebo-controlled trials of treatments that target the underlying biology or cognit