An inexpensive method of small paraffin tissue microarrays using mechanical pencil tips.docVIP

Shebletal.DiagnosticPathology2011,6:117 /content/6/1/117 METHODOLOGY OpenAccess Aninexpensivemethodofsmallparaffintissue microarraysusingmechanicalpenciltips AbdelhadiMShebl,KhaledRZalata,MahaMAminandAmiraKEl-Hawary* Abstract Background:Tissuemicroarraytechnologyhasprovidedahighthroughputmeansofevaluatingpotential biomarkersinarchivalpathologicalspecimens.Thisstudywascarriedoutinordertoproducetissuemicroarray blocksusingmechanicalpenciltipswithouthighcost. Method:Conventionalmechanicalpenciltips(RotringTikkyIIMechanicalPencil1.0mm)wereusedtocutout1 mmwaxcylindersfromtherecipientblock,creatin