Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.docVIP

McCann et al. Arthritis Research Therapy 2010, 12:R107 /content/12/3/R107 RESEARCH ARTICLE Open Access Apremilast, a novel PDE4 inhibitor, inhibits Research article spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis Fiona E McCann*?1, Andrew C Palfreeman?1, Melanie Andrews1,2, Dany P Perocheau1, Julia J Inglis1,3, Peter Schafer4, Marc Feldmann1, Richard O Williams?1 and Fionula M Brennan?1 Abstract Introduction: Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis