Arginine metabolism is markedly impaired in polymicrobial infected mice.docVIP

Otto et al. Critical Care 2012,16:412 /content/16/2/412 LETTER Arginine metabolism is markedly impaired in polymicrobial infected mice Gordon P Otto 1,2 , Sophie Neugebauer 3,4 , Ralf A Claus 1,4 and Maik Sossdorf* 1,4 Since sepsis has been identi? ed as an arginine de? ciency state, there is an ongoing controversial debate about Our data clearly show that the arginine plasma concentration is substantially decreased in sepsis, which arginine supplementation in the treatment of patients is not caused by lower availability of amino acids gluta- with se