p53 gene in tissues of pterygium.docVIP

p53 gene in tissues of pterygium OF: He Wenlin, Wang Lihua, Chen Yung-Sen, Gao Yang [Abstract] Objective To observe the p53 gene in pterygium tissue, the incidence of pterygium and the relationship between apoptosis. Methods 25 cases of pterygium as the experimental group and control group used normal eyes, noses and side of the conjunctiva, produced after the routine paraffin section and HE staining p53 monoclonal antibody staining, the experimental data rank test. Results of the p53 protein in the experimental group were significantly higher, the difference was highly significant ( P lt;0.01). Conclusion The early development of pterygium lesions there may be mutations in p53 gene, so that the normal role of p53 tumor suppressor gene loss, resulting in excessive proliferation of conjunctiva and pterygium fibrovascular tissue invasion of the cornea. [Keywords:] pterygium gene p53 immunohistochemistry Pterygium is a common clinical ocular surface disease, it showed a subconjunctival fibrovascular tissue to the cornea violations of the triangle is characterized by hyperplasia, more common in nasal palpebral fissure area, often eye disease, postoperative recur. Developed to can cause some degree of astigmatism, decreased visual acuity, eye discomfort and cosmetic problems affecting the patient’s physical and mental health [1]. on the etiology and pathogenesis of pterygium remains unclear, at present suggests that solar ultraviolet radiation in the environment is the most important factor. in the oxidative stress induced by UV in DNA damage, p53 gene is the most common injury was one of the genes. [2] examined the effects of p53 gene in pterygium tissue, of pterygium The incidence and the relationship between the mechanisms of apoptosis, is a clear etiology and pathogenesis of pterygium basis. 1 Materials and Methods 1.1 General Information 25 cases of pterygium specimens (experimental group) were randomly taken from Nam Long Hospital, Zhongshan Op