Association study between a polymorphism at the 3-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.docVIP

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Association study between a polymorphism at the 3-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.doc

Association study between a polymorphism at the 3-untranslated region of CLOCK gene and attention deficit hyperactivity disorder

Xuetal.BehavioralandBrainFunctions2010,6:48 /content/6/1/48 RESEARCH OpenAccess Associationstudybetweenapolymorphismat the3′-untranslatedregionofCLOCKgeneand attentiondeficithyperactivitydisorder XiaohuiXu1*,GeromeBreen1,Chih-KenChen2,3,4,Yu-ShuHuang2,3,Yu-YuWu2,3,PhilipAsherson1 Abstract Background:Thecircadianlocomotoroutputcycleskaput(CLOCK)geneencodesproteinregulationcircadian rhythmandalsoplayssomerolesinneuraltransmittersystemsincludingthedopaminesystem.Severallinesof evidenceimplicatearelationshipbetweenattention-deficithyperactivitydisorder(ADHD),circadianrythmicityand sleepingdistur

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Association study between a polymorphism at the 3-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.docVIP