Back-translation for discovering distant protein homologies in the presence of frameshift mutations.docVIP
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Back-translation for discovering distant protein homologies in the presence of frameshift mutations
G?rdeaetal.AlgorithmsforMolecularBiology2010,5:6
/content/5/1/6
RESEARCH
OpenAccess
Back-translationfordiscoveringdistantprotein
homologiesinthepresenceofframeshift
mutations
MartaG?rdea1,2*,LaurentNoé1,2*,GregoryKucherov1,2,3*
Abstract
Background:Frameshiftmutationsinprotein-codingDNAsequencesproduceadrasticchangeintheresulting
proteinsequence,whichpreventsclassicproteinalignmentmethodsfromrevealingtheproteins’commonorigin.
Moreover,whenalargenumberofsubstitutionsareadditionallyinvolvedinthedivergence,thehomology
detectionbecomesdifficultevenattheDNAlevel.
Results:Wedevelopedanovelmethodtoi
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