Back-translation for discovering distant protein homologies in the presence of frameshift mutations.docVIP

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Back-translation for discovering distant protein homologies in the presence of frameshift mutations.doc

Back-translation for discovering distant protein homologies in the presence of frameshift mutations

G?rdeaetal.AlgorithmsforMolecularBiology2010,5:6 /content/5/1/6 RESEARCH OpenAccess Back-translationfordiscoveringdistantprotein homologiesinthepresenceofframeshift mutations MartaG?rdea1,2*,LaurentNoé1,2*,GregoryKucherov1,2,3* Abstract Background:Frameshiftmutationsinprotein-codingDNAsequencesproduceadrasticchangeintheresulting proteinsequence,whichpreventsclassicproteinalignmentmethodsfromrevealingtheproteins’commonorigin. Moreover,whenalargenumberofsubstitutionsareadditionallyinvolvedinthedivergence,thehomology detectionbecomesdifficultevenattheDNAlevel. Results:Wedevelopedanovelmethodtoi

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