Bench-to-bedside review The role of β-lactamases in antibiotic-resistant Gram-negative infections.docVIP

Bush Critical Care 2010,14:224 /content/14/3/224 RE VIE W Bench-to-bedside review: The role of β-lactamases in antibiotic-resistant Gram-negative infections Karen Bush* Gram-positive bacteria, especially those caused by Abstract vancomycin-resistant enterococci (VRE) and methicillin- Multidrug resistance has been increasing among Gram-negative bacteria and is strongly associated with the production of both chromosomal- and plasmid-encoded β-lactamases, whose number now resistant Staphylococcus aureus (MRSA) [1]. However, a second, but potentially more important, threat to cr