原创力文档Bringing order to protein disorder through comparative genomics and genetic interactions.docVIP
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Bringing order to protein disorder through comparative genomics and genetic interactions
Bellayetal.GenomeBiology2011,12:R14
/2011/12/2/R14
RESEARCH
OpenAccess
Bringingordertoproteindisorderthrough
comparativegenomicsandgeneticinteractions
JeremyBellay1?,SangjoHan2,3?,MagaliMichaut2,3?,TaeHyungKim2,3,MichaelCostanzo2,3,BrendaJAndrews2,3,4,
CharlesBoone2,3,4,GaryDBader2,3,4,5,ChadLMyers1*andPhilipMKim2,3,4,5*
Abstract
Background:Intrinsicallydisorderedregionsarewidespread,especiallyinproteomesofhighereukaryotes.
Recently,proteindisorderhasbeenassociatedwithawidevarietyofcellularprocessesandhasbeenimplicatedin
severalhumandiseases.Despiteitsapparentfunctionalimportance,thesheerran
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