原创力文档Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis.docVIP
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Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
Shinetal.ArthritisResearchTherapy2010,12:R168
/content/12/5/R168
RESEARCH ARTICLE
OpenAccess
Borreliaburgdorferistimulationofchemokine
secretionbycellsofmonocytelineageinpatients
withLymearthritis
JungheeJShin,KlemenStrle,LisaJGlickstein,AndrewDLuster,AllenCSteere*
Abstract
Introduction:JointfluidinpatientswithLymearthritisoftencontainshighlevelsofCCL4andCCL2,whichare
chemoattractantsformonocytesandsomeTcells,andCXCL9andCXCL10,whicharechemoattractantsforCD4+
andCD8+Teffectorcells.ThesechemokinesareproducedprimarilybycellsofmonocytelineageinTH1-type
immuneresponses.Ourgoalwastobegintolearnho
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