原创力文档c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.docVIP
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c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis
Paniaguaetal.ArthritisResearchTherapy2010,12:R32
/content/12/1/R32
RESEARCH ARTICLE
OpenAccess
c-Fms-mediateddifferentiationandprimingof
monocytelineagecellsplayacentralrolein
autoimmunearthritis
RicardoTPaniagua1,2,AnnaChang1,2,MelissaMMariano1,2,EmilyAStein1,2,QianWang1,2,TamsinMLindstrom1,2,
OrrSharpe1,2,ClaireRoscow1,2,PeggyPHo3,DavidMLee4,WilliamHRobinson1,2*
Abstract
Introduction:Tyrosinekinasesarekeymediatorsofmultiplesignalingpathwaysimplicatedinrheumatoidarthritis
(RA).Wepreviouslydemonstratedthatimatinibmesylate–aFoodandDrugAdministration(FDA)-approved,
antineoplasticdrugthatpoten
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