原创力文档Characterization of fast-decaying PET radiotracers solely through LC-MSMS of constituent radioactive and carrier isotopologues.docVIP
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Characterization of fast-decaying PET radiotracers solely through LC-MSMS of constituent radioactive and carrier isotopologues
Shettyetal.EJNMMIResearch2013,3:3
/content/3/1/3
ORIGINAL RESEARCH
OpenAccess
Characterizationoffast-decayingPETradiotracers
solelythroughLC-MS/MSofconstituent
radioactiveandcarrierisotopologues
HUmeshaShetty*,CherylLMorse,YiZhangandVictorWPike
Abstract
Background:Thecharacterizationoffast-decayingradiotracersthatarelabeledwithcarbon-11(t1/2=20.38min),
includingcriticalmeasurementofspecificradioactivity(activitypermoleataspecifictime)beforereleaseforusein
positron-emissiontomography(PET),hasreliedheavilyonchromatographicplusradiometricmeasurements,each
ofwhichmaybevulnerabletosignificanterr
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