Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis.docVIP

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Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis.doc

Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis

Kimataetal.ArthritisResearchTherapy2012,14:R107 /content/14/3/R107 RESEARCH ARTICLE OpenAccess CharacterizationofinhibitoryTcellsinducedby ananalogoftypeIIcollageninanHLA-DR1 humanizedmousemodelofautoimmunearthritis MasaruKimata1,DavidLCullins1,MonicaLBrown2,DavidDBrand1,3,EdwardFRosloniec1,3,LindaKMyers2*, JohnMStuart1,3 andAndrewHKang1,3 Abstract Introduction:WeusedDR1transgenicmiceandcovalentlylinkedDR1multimerstocharacterizeanalog-specific inhibitoryTcellsincollagen-inducedarthritis(CIA).Becauseofthelownumbersofantigen-specificTcellsinwild- typemice,functionalT-cellstudiesinautoimmunea

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Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis.docVIP