原创力文档Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps.docVIP
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- 2017-05-16 发布于上海
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Qietal.BMCPhysiology2011,11:1
/1472-6793/11/1
RESEARCH ARTICLE
OpenAccess
Characterizationoftheinsulinsensitivityof
ghrelinreceptorKOmiceusingglycemicclamps
YongQi,KennethALongo,DerekJGiuliana,SamanthaGagne,TomMcDonagh,ElizabethGovek,AnnaNolan,
ChaosengZou,KristenMorgan,JeffreyHixon,JeffreyOSaunders,PeterSDiStefano,BradJGeddes*
Abstract
Background:Weandothershavedemonstratedpreviouslythatghrelinreceptor(GhrR)knockout(KO)micefeda
highfatdiet(HFD)haveincreasedinsulinsensitivityandmetabolicflexibilityrelativetoWTlittermates.Astriking
featureoftheHFD-fedGhrRKOmouseisthedramaticdecreaseinhepatic
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