Choroid plexus transport gene deletion studies.docVIP

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Choroid plexus transport gene deletion studies

KeepandSmithFluidsandBarriersoftheCNS2011,8:26 /content/8/1/26 FLUIDS AND BARRIERS OF THE CNS REVIEW OpenAccess Choroidplexustransport:genedeletionstudies RichardFKeep1,2* andDavidESmith3 Abstract Thisreviewexaminestheuseoftransporterknockout(KO)animalstoevaluatetransporterfunctionatthechoroid plexus(theblood-CSFbarrier;BCSFB).Comparedtotheblood-brainbarrier,therehavebeenfewsuchstudieson choroidplexus(CP)function.ThesehaveprimarilyfocusedonPept2(anoligopeptidetransporter),ATP-binding cassette(ABC)transporters,Oat3(anorganicaniontransporter),Svct2(anascorbicacidtransporter),transthyretin, i

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