Choroid plexus transport gene deletion studies.docVIP

KeepandSmithFluidsandBarriersoftheCNS2011,8:26 /content/8/1/26 FLUIDS AND BARRIERS OF THE CNS REVIEW OpenAccess Choroidplexustransport:genedeletionstudies RichardFKeep1,2* andDavidESmith3 Abstract Thisreviewexaminestheuseoftransporterknockout(KO)animalstoevaluatetransporterfunctionatthechoroid plexus(theblood-CSFbarrier;BCSFB).Comparedtotheblood-brainbarrier,therehavebeenfewsuchstudieson choroidplexus(CP)function.ThesehaveprimarilyfocusedonPept2(anoligopeptidetransporter),ATP-binding cassette(ABC)transporters,Oat3(anorganicaniontransporter),Svct2(anascorbicacidtransporter),transthyretin, i