Citotoxic Activity of Extracts and Sesquiterpene Lactones from Stachycephalum argentinum.docVIP

433 Molecules 2000, 5 Citotoxic Activity of Extracts and Sesquiterpene Lactones from Stachycephalum argentinum R. Alarcón, C. Vaccarini and V. Sosa Dpto de Química Orgánica, Facultad de Cs Químicas, UNC. Ciudad Universitaria. 5000 Córdoba. Ar- gentina E-mail: roalar@dqo.fcq.unc-edu.ar Abstract: The extracts and sesquiterpene lactones of S.argentinum were assayed to deter- mine their biological activity on Artemia salina. The most active compound was costunolide (1) with LD50= 62 ppm. Introduction Our previous phytochemical study of Stachychephalum argentinum (Asteraceae), rev