Dietary Polyphenols and Obesity.docVIP

Nutrients 2010, 2, 737-751; doi:10.3390/nu2070737 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Review Dietary Polyphenols and Obesity Mohsen Meydani * and Syeda T. Hasan Vascular Biology Laboratory, Jean Mayer USDA- Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA; E-Mail: sthasan@ * Author to whom correspondence should be addressed: E-Mail: mohsen.meydani@; Tel.: 617-556-3126; Fax: 617-556-3224. Received: 4 June 2010; in revised form: 1 July 2010 / Accepted: 7 July 2010 / Published: 8 July 2010 Abstract: The prevalence of overweight and obesity and their associated metabolic disorders are considered a major threat to the public’s health. While several diet and exercise programs are available for weight loss and prevention of weight regain, progress is often slow and disappointing. Recently, natural bioactive phytochemicals present in foods have been discovered for their potential health benefit effects on the prevention of chronic disorders such as cancer, cardiovascular disease, inflammatory and metabolic diseases including obesity. Polyphenols are a class of naturally-occurring phytochemicals, of which some such as catechins, anthocynines, resveratrol and curcumin have been shown to modulate physiological and molecular pathways that are involved in energy metabolism, adiposity, and obesity. The potential in vivo, beneficial effects of these polyphenols on adiposity and obesity as complementary agents in the up-regulation of energy expenditure have emerged by investigating these compounds in cell cultures, animal models of obesity and in some human clinical and epidemiological studies. In this brief review, the efficacy of the above-named polyphenols and their potential efficacy to modulate obesity and some associated disorders are discussed. Keywords: polyphenol; green tea; catechins; resveratrol; curcumin; obesity  N