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Discriminant validity, responsiveness and reliability of the rheumatoid arthritis-specific Work Productivity Survey (WPS-RA).doc

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Discriminant validity, responsiveness and reliability of the rheumatoid arthritis-specific Work Productivity Survey (WPS-RA)

Available online /content/11/3/R73 Research article Open Access Vol 11 No 3 Discriminant validity, responsiveness and reliability of the rheumatoid arthritis-specific Work Productivity Survey (WPS-RA) Jane T Osterhaus1, Oana Purcaru2 and Lance Richard3 1Wasatch Health Outcomes, 2613 Silver Cloud Drive, Park City, UT 84060, USA 2Global Health Outcomes Research, UCB Pharma, Chemin du Foriest, 1420 Braine-lAlleud, Belgium 3Global Health Outcomes Research, UCB Pharma, 208 Bath Road Slough, Berkshire SL1 3WE, UK Corresponding author: Jane T Osterhaus, JTOsterhaus@M Received: 18 Dec 2008 Revisions requested: 17 Mar 2009 Revisions received: 8 Apr 2009 Accepted: 20 May 2009 Published: 20 May 2009 Arthritis Research Therapy 2009, 11:R73 (doi:10.1186/ar2702) This article is online at: /content/11/3/R73 ? 2009 Osterhaus et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Productivity The Survey rheumatoid arthritis-specific Work (WPS-RA) measures the impact of also used to quantify responsiveness. All group comparisons were conducted using a non-parametric bootstrap-t method. rheumatoid arthritis (RA) and treatment on patient productivity within and outside the home. It contains nine questions addressing employment status, productivity within and outside the home, and daily activities. The objective of this paper was to evaluate the discriminant validity, responsiveness, and reliability of the WPS-RA in patients with active RA. Results Subjects with lower HAQ-DI or SF-36 scores generally had statistically greater RA-associated losses in productivity within and outside the home compared with subjects with higher scores (25 of 32 evaluations were statistically significan