Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers.docVIP

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Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers.doc

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Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers

Comparative Hepatology BioMedCentral Research Open Access Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers Bart Spee*1, Paul JJ Mandigers1, Brigitte Arends1, Peter Bode2, Ted SGAM van den Ingh3, Gaby Hoffmann1, Jan Rothuizen1 and Louis C Penning1 Address: 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands, 2Interfacultary Reactor Institute, Delft University, The Netherlands and 3Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands Email: Bart Spee* - B.Spee@vet.uu.nl; Paul JJ Mandigers - P.j.j.mandigers@planet.nl; Brigitte Arends - B.Arends@vet.uu.nl; Peter Bode - P.Bode@iri.tudelft.nl; Ted SGAM van den Ingh - THI@vet.uu.nl; Gaby Hoffmann - G.Hoffmann@vet.uu.nl; Jan Rothuizen - J.Rothuizen@vet.uu.nl; Louis C Penning - L.C.Penning@vet.uu.nl * Corresponding author Published: 24 March 2005 Received: 27 January 2005 Accepted: 24 March 2005 Comparative Hepatology 2005, 4:3 doi:10.1186/1476-5926-4-3 This article is available from: /content/4/1/3 ? 2005 Spee et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The role of copper accumulation in the onset of hepatitis is still unclear. Therefore, we investigated a spontaneous disease model of primary copper-toxicosis in Doberman pinschers so to gain insights into the pathophysiology of copper toxicosis, namely on genes involved in copper metabolism and reactive oxygen species (ROS) defences. Results: We used quantitative real-time PCR to determine differentially expressed genes within a target panel, investigating different groups ranging from