Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice.docVIP

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Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice.doc

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Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice

Open Access Re rch 2008MudgeetVoal.lumesea9, Issue 5, Article R91 Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice Jonathan M Mudge*, Stuart D Armstrong?, Karen McLaren*, Robert J Beynon?, Jane L Hurst?, Christine Nicholson*, Duncan H Robertson?, Laurens G Wilming* and Jennifer L Harrow* Addresses: *Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. ?Proteomics and Functional Genomics Group, Department of Veterinary Preclinical Science, University of Liverpool, Crown Street and Brownlow Hill, Liverpool, L69 7ZJ, UK. ?Mammalian Behavior and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst, Neston, CH64 7TE, UK. Correspondence: Jonathan M Mudge. Email: jm12@sanger.ac.uk Published: 28 May 2008 Received: 23 January 2008 Revised: 7 April 2008 Accepted: 28 May 2008 Genome Biology 2008, 9:R91 (doi:10.1186/gb-2008-9-5-r91) The electronic version of this article is the complete one and can be found online at /2008/9/5/R91 ? 2008 Mudge et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. nMouseapryTparrmajorogteetiendssurinary(eMqUuePnsc)proteinsing,andmanualthe itgenomeMup/iannotation,t clusters ophylogeneticf two strains oanalysisf inbredandmicmasse./pspectrometry were used to characterise major uri- Abstract Background: The major urinary proteins (MUPs) of Mus musculus domesticus are deposited in urine in large quantities, where they bind and release pheromones and also provide an individual recognition signal via their phenotypic polymorphism. Whilst important information about MUP functionality has been