Early veno-venous haemodiafiltration for sepsis-related multiple organ failure.docVIP

Available online /content/9/6/R755 Research Open Access Vol 9 No 6 Early veno-venous haemodiafiltration for sepsis-related multiple organ failure Bernard Page1, Antoine Vieillard-Baron1, Karim Chergui1, Olivier Peyrouset1, Anne Rabiller1, Alain Beauchet2, Philippe Aegerter2 and Fran?ois Jardin1 1Medical Intensive Care Unit, University Hospital Ambroise Paré, Assistance Publique H?pitaux de Paris, 9 avenue Charles de Gaulle, 92104 Boulogne, France 2Department of Biostatistics, University Hospital Ambroise Paré, Assistance Publique H?pitaux de Paris, 9 avenue Charles de Gaulle, 92104 Boulogne, France Corresponding author: Antoine Vieillard-Baron, antoine.vieillard-baron@apr.aphp.fr Received: 11 Jul 2005 Revisions requested: 1 Sep 2005 Revisions received: 7 Sep 2005 Accepted: 3 Oct 2005 Published: 9 Nov 2005 Critical Care 2005, 9:R755-R763 (DOI 10.1186/cc3886) This article is online at: /content/9/6/R755 ? 2005 Page et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction We conducted a prospective observational study from January 1995 to December 2004 to evaluate the impact on recovery of a major advance in renal replacement therapy, namely continuous veno-venous haemodiafiltration (CVVHDF), in patients with refractory septic shock. organs; the final mortality rate in this subgroup was 30%. In contrast, metabolic acidosis did not improve in the remaining 20 patients after 12 hours of CVVHDF, and the mortality rate in this subgroup was 100%. The crude mortality rate for the whole group was 53%, which is significantly lower than the predicted mortality using Simplified Acute Physiology Score II (79%). Method CVVHDF was implemented after 6–12 hours of maximal haemodynamic support,