Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee a feasibility trial.docVIP

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Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee a feasibility trial.doc

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Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee a feasibility trial

Ngetal.ArthritisResearchTherapy2010,12:R25 /content/12/1/R25 RESEARCH ARTICLE OpenAccess Efficacyofaprogressivewalkingprogramand glucosaminesulphatesupplementationon osteoarthriticsymptomsofthehipandknee: afeasibilitytrial NormanTMNg1,KristiannCHeesch1,2*,WendyJBrown1 Abstract Introduction:Managementofosteoarthritis(OA)includestheuseofnon-pharmacologicalandpharmacological therapies.Althoughwalkingiscommonlyrecommendedforreducingpainandincreasingphysicalfunctionin peoplewithOA,glucosaminesulphatehasalsobeenusedtoalleviatepainandslowtheprogressionofOA.This studyevaluatedtheeffectsofaprogressivewalkingprogramandglucosaminesulphateintakeonOAsymptoms andphysicalactivityparticipationinpeoplewithmildtomoderatehiporkneeOA. Methods:Thirty-sixlowactiveparticipants(aged42to73years)wereprovidedwith1500mgglucosamine sulphateperdayfor6weeks,afterwhichtheybegana12-weekprogressivewalkingprogram,whilecontinuingto takeglucosamine.Theywererandomizedtowalk3or5daysperweekandgivenapedometertomonitorstep counts.Forbothgroups,steplevelofwalkingwasgraduallyincreasedto3000steps/dayduringthefirst6weeks ofwalking,andto6000steps/dayforthenext6weeks.Primaryoutcomesincludedphysicalactivitylevels,physical function(self-pacedsteptest),andtheWOMACOsteoarthritisIndexforpain,stiffnessandphysicalfunction. Assessmentswereconductedatbaselineandat6-,12-,18-,and24-weekfollow-ups.TheMannWhitneyTestwas usedtoexaminedifferencesinoutcomemeasuresbetweengroupsateachassessment,andtheWilcoxonSigned RanksTestwasusedtoexaminedifferencesinoutcomemeasuresbetweenassessments. Results:Duringthefirst6weeksofthestudy(glucosaminesupplementationonly),physicalactivitylevels,physical function,andtotalWOMACscoresimproved(P0.05).Betweenthestartofthewalkingprogram(Week6)andthe finalfollow-up(Week24),furtherimprovementswereseenintheseoutcomes(P0.05)althoughmostimprovements wereseenbetweenWeeks6and12.Nosignificantdifferenceswerefoundbetweenwalkinggroups. Conclusions:InpeoplewithhiporkneeOA,walkingaminimumof3000steps(~30minutes),