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Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab.doc

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Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab

Available online /content/10/5/R105 Research article Open Access Vol 10 No 5 Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab Sanna Rosengren1, Nathan Wei2, Kenneth C Kalunian1, Nathan J Zvaifler1, Arthur Kavanaugh1 and David L Boyle1 1Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA 2Arthritis and Osteoporosis Center of Maryland, 71 Thomas Johnson Drive, Frederick, MD 21702, USA Corresponding author: David L Boyle, dboyle@ Received: 2 Jun 2008 Revisions requested: 7 Jul 2008 Revisions received: 14 Aug 2008 Accepted: 1 Sep 2008 Published: 1 Sep 2008 Arthritis Research Therapy 2008, 10:R105 (doi:10.1186/ar2497) This article is online at: /content/10/5/R105 ? 2008 Rosengren et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The purpose of this study was to quantitatively evaluate the contribution of synovial lymphoid aggregates to autoantibody (rheumatoid factor [RF] and anti-cyclic citrullinated peptide [anti-CCP]) and total immunoglobulin (IgG and IgM) production in rheumatoid arthritis (RA) patients and the effect thereon of the B-cell-depleting antibody, rituximab, in the ARISE were also enriched in RA, but not in OA. SSI correlated significantly with mRNA content for both IgM and IgG, demonstrating that it reflected synovial immunoglobulin production. RA synovia with lymphocyte aggregates contained significantly elevated RF-IgM and anti-CCP IgG compared with tissues with diffuse lymphoid infiltration. Rituximab treatment did not affect synovial autoantibody or total immunoglobul