Endocrine tumors of the gastrointestinal tract and pancreasgrading, tumor size and proliferation index do not predict malignant behavior.docVIP

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Endocrine tumors of the gastrointestinal tract and pancreasgrading, tumor size and proliferation index do not predict malignant behavior.doc

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Endocrine tumors of the gastrointestinal tract and pancreasgrading, tumor size and proliferation index do not predict malignant behavior

Diagnostic Pathology BioMedCentral Research Open Access Endocrine tumors of the gastrointestinal tract and pancreas:grading, tumor size and proliferation index do not predict malignant behavior Borislav A Alexiev*, Cinthia B Drachenberg? and John C Papadimitriou? Address: Department of Pathology, Division of Anatomic Pathology, University of Maryland Medical Center, 22 S. Greene Street, Baltimore, MD 21201-1595, USA Email: Borislav A Alexiev* - balexiev@; Cinthia B Drachenberg - cdrac001@; John C Papadimitriou - jpapa001@ * Corresponding author ?Equal contributors Published: 8 August 2007 Received: 6 July 2007 Accepted: 8 August 2007 Diagnostic Pathology 2007, 2:28 doi:10.1186/1746-1596-2-28 This article is available from: /content/2/1/28 ? 2007 Alexiev et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Context: Gastrointestinal and pancreatic (GIP) endocrine tumors (ETs) have been regarded as slow growing neoplasms with distinct morphologic characteristics that behave less aggressively than carcinomas. The malignant potential of these tumors is difficult to predict. Objective: To evaluate prognostic parameters, namely tumor size, tumor grade, and Ki-67 index in relationship to metastatic behavior of GIP ETs. Design: Biopsies and surgical specimens from 38 patients with GIP ETs were selected. The study group comprised 16 males and 22 females (mean age 62.6 years; range 24–91). Formalin-fixed, paraffin-embedded tissue sections were stained with HE, synaptophysin, chromogranin A, and Ki- 67. Ki-67 index was evaluated using ChromaVision Automated Assisted Image Analysis software. Proliferative index was compared to tumor grade, and the degree of associations between tumor size, tu