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Ertapenem susceptibility of extended spectrum beta-lactamase-producing organisms
Annals of Clinical Microbiology and
Antimicrobials
BioMedCentral
Research
Open Access
Ertapenem susceptibility of extended spectrum
beta-lactamase-producing organisms
Rupal M Mody*1, Daniel P Erwin1, Amy M Summers1, Hector A Carrero1,
Edward B Selby1, Allesa J Ewell1 and Kimberly A Moran1,2
Address: 1Walter Reed Army Medical Center, Washington, DC 20307, USA and 2Uniformed Services University of the Health Sciences, Bethesda,
MD 20814, USA
Email: Rupal M Mody* - rmody1917@; Daniel P Erwin - biomandan28@;
Amy M Summers - amy.summers@; Hector A Carrero - hector.carrero@;
Edward B Selby - edward.selby@; Allesa J Ewell - allesa.ewell@; Kimberly A Moran - kmoran@
* Corresponding author
Published: 6 June 2007
Received: 10 April 2007
Accepted: 6 June 2007
Annals of Clinical Microbiology and Antimicrobials 2007, 6:6
doi:10.1186/1476-0711-6-6
This article is available from: /content/6/1/6
? 2007 Mody et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Infections caused by multiply drug resistant organisms such as extended spectrum
beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae are increasing.
Carbapenems (imipenem and meropenem) are the antibiotics commonly used to treat these
agents. There is limited clinical data regarding the efficacy of the newest carbapenem, ertapenem,
against these organisms. Ertapenem susceptibility of ESBL-producing E. coli and K. pneumoniae
clinical isolates were evaluated and compared to imipenem to determine if imipenem susceptibility
could be used as a surrogate for ertapenem susceptibility.
Methods: 100 ESBL isolates (n = 34 E. coli and n = 66 K. pneumoniae) collected from 2005–2006
clinical specimens
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