Epigallocatechin-3-gallate a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases.docVIP

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Epigallocatechin-3-gallate a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases.doc

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Epigallocatechin-3-gallate a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases

M?hleretal.TheEPMAJournal2013,4:5 /content/4/1/5 REVIEW OpenAccess Epigallocatechin-3-gallate:auseful,effectiveand safeclinicalapproachfortargetedpreventionand individualisedtreatmentofneurologicaldiseases? AnjaM?hler1,2*,SilviaMandel3,MarioLorenz4,UrsRuegg5,ErichEWanker6,MichaelBoschmann1 andFriedemannPaul1,2 Abstract Neurodegenerativedisordersshowanincreasingprevalenceinanumberofhighlydevelopedcountries.Often, thesediseasesrequirelife-longtreatmentmostlywithdrugswhicharecostlyandmostlyaccompaniedbymoreor lessseriousside-effects.Theirheterogeneousmanifestation,severityandoutcomeposetheneedforindividualised treatmentoptions.Thereisanintensivesearchfornewstrategiesnotonlyfortreatingbutalsoforpreventingthese diseases.Greenteaandgreenteaextractsseemtobesuchapromisingandsafealternative.However,data regardingthebeneficialeffectsandpossibleunderlyingmechanism,specificallyinclinicaltrials,arerareandrather controversialornon-conclusive.Thisreviewoutlinestheexistingevidencefrompreclinicalstudies(cellandtissue culturesandanimalmodels)andclinicaltrialsregardingpreventiveandtherapeuticeffectsofepigallcatechin-3 --oxidativepropertiesoftheteacatechin importantfordosagerecommendations. Keywords:Neurologicaldiseases,Predictiveandpersonalisedmedicine,Targetedprevention,Greentea, Epigallocatechin-3-gallate,Tailoredtherapy Review Introduction for preventing these diseases. At the time of diagnosis, when neurodegeneration has already become evident in Neurodegenerative disorders show an increasing preva- terms of symptoms, neurodegenerative cascades are al- lence in a number of highly developed countries partly ready initiated and neuro-axonal degeneration cannot be attributabletothestillincreasinglifeexpectancyinthese reversed with neuroprotective treatments [1]. Green tea countries but also other still not clearly identified and andgreenteaextracts(GTEs)seemtobeapromisingand characterised causal factors. Depending on the disease, safealternativefortargetedpreventionandindivi