Evaluation of limited blood sampling population input approaches for kinetic quantification of [18F]fluorothymidine PET data.docVIP

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Evaluation of limited blood sampling population input approaches for kinetic quantification of [18F]fluorothymidine PET data.doc

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Evaluation of limited blood sampling population input approaches for kinetic quantification of [18F]fluorothymidine PET data

Contractoretal.EJNMMIResearch2012,2:11 /content/2/1/11 ORIGINAL RESEARCH OpenAccess Evaluationoflimitedbloodsamplingpopulation inputapproachesforkineticquantification 18 of[ F]fluorothymidinePETdata KaiyumarsBContractor1,LauraMKenny1,CharlesRCoombes1,FedericoETurkheimer2,EricOAboagye1,3* and LulaRosso2 Abstract Background:Quantificationofkineticparametersofpositronemissiontomography(PET)imagingagentsnormally requirescollectingarterialbloodsampleswhichisinconvenientforpatientsanddifficulttoimplementinroutine clinicalpractice.Theaimofthisstudywastoinvestigatewhetherapopulation-basedinputfunction(POP-IF) reliantononlyafewindividualdiscretesamplesallowsaccurateestimatesoftumourproliferationusing[18F] fluorothymidine(FLT). Methods:Thirty-sixhistoricalFLT-PETdatawithconcurrentarterialsamplingwereavailableforthisstudy.A populationaverageofbaselinescansblooddatawasconstructedusingleave-one-outcross-validationforeach scanandusedinconjunctionwithindividualbloodsamples.Threelimitedsamplingprotocolswereinvestigated including,respectively,onlyseven(POP-IF7),five(POP-IF5)andthree(POP-IF3)discretesamplesofthehistorical dataset.Additionally,usingthethree-pointprotocol,wederivedaPOP-IF3M,theonlyinputfunctionwhichwas notcorrectedforthefractionofradiolabelledmetabolitespresentinblood.ThekineticparameterfornetFLT retentionatsteadystate,Ki,wasderivedusingthemodifiedPatlakplotandcomparedwiththeoriginalfullarterial setforvalidation. Results:SmallpercentagedifferencesintheareaunderthecurvebetweenallthePOP-IFsandfullarterial samplingIFwasfoundover60min(4.2%-5.7%),whiletherewere,asexpected,largerdifferencesinthepeak positionandpeakheight. AhighcorrelationbetweenKivaluescalculatedusingtheoriginalarterialinputfunctionandallthepopulation- 2 derivedIFswasobserved(R =0.85-0.98).Thepopulation-basedinputshowedgoodintra-subjectreproducibilityof Kivalues(R2=0.81-0.94)andgoodcorrelation(R2=0.60-0.85)withKi-67. Conclusions:Inputfunctionsgeneratedusingthesesimplifiedprotocolsoverscanduratio