Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females a randomized, double-blind, placebo-controlled trial.docVIP

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Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females a randomized, double-blind, placebo-controlled trial.doc

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Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females a randomized, double-blind, placebo-controlled trial

BMC Pediatrics BioMedCentral Study protocol Open Access Evaluation of the efficacy and safety of olanzapine as an adjunctive treatment for anorexia nervosa in adolescent females: a randomized, double-blind, placebo-controlled trial Wendy Spettigue*1,2, Annick Buchholz1,3, Katherine Henderson1,3, Stephen Feder1,4, David Moher1,5,6, Kader Kourad5, Isabelle Gaboury7, Mark Norris1,4 and Sheila Ledoux7 Address: 1Mental Health Department, Childrens Hospital of Eastern Ontario Research Institute, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada, 2Department of Psychiatry, University of Ottawa, 550 Cumberland, Ottawa, ON, K1N 6N5, Canada, 3Department of Psychology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada, 4Department of Pediatrics, Childrens Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada, 5Chalmers Research Group, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada, 6Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 550 Cumberland, Ottawa, ON, K1N 6N5, Canada and 7Clinical Research Unit, Childrens Hospital of Eastern Ontario Research Institute, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada Email: Wendy Spettigue* - wspettigue@cheo.on.ca; Annick Buchholz - buchholz@cheo.on.ca; Katherine Henderson - henderson_k@cheo.on.ca; Stephen Feder - sfeder@cheo.on.ca; David Moher - dmoher@uottawa.ca; Kader Kourad - Kader_Kourad@hc-sc.gc.ca; Isabelle Gaboury - igaboury@cheo.on.ca; Mark Norris - mnorris@cheo.on.ca; Sheila Ledoux - sledoux@cheo.on.ca * Corresponding author Published: 31 January 2008 Received: 18 December 2007 Accepted: 31 January 2008 BMC Pediatrics 2008, 8:4 doi:10.1186/1471-2431-8-4 This article is available from: /1471-2431/8/4 ? 2008 Spettigue et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any med