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Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.doc

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Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis

Available online /content/8/5/R154 Research article Open Access Vol 8 No 5 Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis James N Jarvis1, Howard R Petty2, Yuhong Tang3, Mark Barton Frank3, Philippe A Tessier4, Igor Dozmorov3, Kaiyu Jiang1, Andrei Kindzelski2, Yanmin Chen1, Craig Cadwell3, Mary Turner3, Peter Szodoray3, Julie L McGhee5 and Michael Centola3 1Department of Pediatrics, University of Oklahoma College of Medicine, 940 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA 2Kellogg Eye Center, University of Michigan School of Medicine, 1000 Wall St., Ann Arbor, MI 48105, USA 3Arthritis Immunology Program, Oklahoma Medical Research Foundation, 820 NE 13th St., Oklahoma City, OK 73104, USA 4Centre de Recherche en Infectiologie, Centre de Recherche du CHUL, 2705 boul. Laurier, Ste-Foy, Québec, G1V 4G2, Canada 5University of Oklahoma College of Medicine, 940 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA Corresponding author: James N Jarvis, james-jarvis@ Received: 17 May 2006 Revisions requested: 8 Jun 2006 Revisions received: 15 Aug 2006 Accepted: 26 Sep 2006 Published: 26 Sep 2006 Arthritis Research Therapy 2006, 8:R154 (doi:10.1186/ar2048) This article is online at: /content/8/5/R154 ? 2006 Jarvis et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many aspects of the disease that suggest equally important contributions of the innate immune system. We used gene expression arrays and computer modeling to examine the function in neutrophils of 25 children with polya