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Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes.doc

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Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes

Open Access Re rch 2008WangetVoal.lumesea9, Issue 12, Article R169 Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes Ping Wang*?, Shanye Yin*?, Zhenguo Zhang*?, Dedong Xin*, Landian Hu*, Xiangyin Kong*? and Laurence D Hurst§ Addresses: *Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine (SJTUSM), 225 South Chong Qing Road, Shanghai 200025, PR China. ?Graduate School of the Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, PR China. ?State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University, 197 Rui Jin Road II, Shanghai 200025, PR China. §Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK. Correspondence: Xiangyin Kong. Email: xykong@. Laurence D Hurst. Email: l.d.hurst@bath.ac.uk Published: 2 December 2008 Received: 10 September 2008 Revised: 2 October 2008 Accepted: 2 December 2008 Genome Biology 2008, 9:R169 (doi:10.1186/gb-2008-9-12-r169) The electronic version of this article is the complete one and can be found online at /2008/9/12/R169 ? 2008 Wang et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. mRNAtrpansAcrciosense-antisensepmtspmutiagthiot nbaelapcroepairingmdictionmon oofcchumanurrencecoding./p RNA trans short sense-antisense pairs suggests that mRNA regulation by other coding Abstract Background: There is increasing realization that regulation of genes is done partly at the RNA level by sense-antisense binding. Studies typically concentrate on the role of non-coding RNAs in regulating coding RNA. But the majority of transcripts in a cell are likely to be