Evaluation of SOFA-based models for predicting mortality in the ICU A systematic review.docVIP

Available online /content/12/6/R161 Research Open Access Vol 12 No 6 Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review Lilian Minne1, Ameen Abu-Hanna1 and Evert de Jonge2 1Department of Medical Informatics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands 2Intensive Care Department, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands Corresponding author: Ameen Abu-Hanna, a.abu-hanna@amc.uva.nl Received: 29 Oct 2008 Revisions requested: 27 Nov 2008 Revisions received: 12 Dec 2008 Accepted: 17 Dec 2008 Published: 17 Dec 2008 Critical Care 2008, 12:R161 (doi:10.1186/cc7160) This article is online at: /content/12/6/R161 ? 2008 Minne et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)- based models for predicting mortality in patients in the intensive care unit (ICU). none of which reported a lack of fit for the SOFA models. Models based on sequential SOFA scores were described in 11 studies including maximum SOFA scores and maximum sum of individual components of the SOFA score (AUC range: 0.69 to 0.92) and delta SOFA (AUC range: 0.51 to 0.83). Studies comparing SOFA with other organ failure scores did not consistently show superiority of one scoring system to another. Four studies combined SOFA-based derivatives with admission severity of illness scores, and they all reported on improved predictions for the combination. Quality of studies ranged from 11.5 to 19.5 points on a 20-point scale. Methods Medline, EMBASE and other databases were searched for English-langu