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Exploration of the omics evidence landscape adding qualitative labels to predicted protein-protein interactions.doc

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Exploration of the omics evidence landscape adding qualitative labels to predicted protein-protein interactions

Open Access Res rch 2007vaneVtoalulNoort.meea8, Issue 9, Article R197 Exploration of the omics evidence landscape: adding qualitative labels to predicted protein-protein interactions ¤ ¤ Vera van Noort *?, Berend Snel ?§ and Martijn A Huynen* Addresses: *Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Toernooiveld, 6525 ED Nijmegen, The Netherlands. ?European Molecular Biology Laboratory, Meyerhofstra?e 1, 69117 Heidelberg, Germany. ?Bioinformatics Group, Department of Biology, Science Faculty, Utrecht University, Padualaan, 3584 CH Utrecht, The Netherlands. §Academic Biomedical Centre, Utrecht University, Yalelaan, 3584 CL Utrecht, The Netherlands. ¤ These authors contributed equally to this work. Correspondence: Vera van Noort. Email: Vera.vanNoort@embl.de Published: 19 September 2007 Received: 4 June 2007 Revised: 18 September 2007 Accepted: 19 September 2007 Genome Biology 2007, 8:R197 (doi:10.1186/gb-2007-8-9-r197) The electronic version of this article is the complete one and can be found online at /2007/8/9/R197 ? 2007 van Noort et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. QualitativeiancptteiorBanycst.cio/mnpnlabelsbientwinogrfordkioffpredictedfeSre. ncetrteyvpiesproteinsiaefcloaurglinteractionsde datasetsbe inferrethatd, pgiverovidevidenceing guidafornceprotein-interactions,t wards direct experqualitativeimental verlabelsificationon theof thpredictede predicteproteind inter- Abstract Background: In the post-genomic era various functional genomics, proteomics and computational techniques have been developed to elucidate the protein interaction network. While some of these techniques are specific for a certai