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Exploring the assumptions underlying genetic variation in host nematode resistance (Open Access publication).doc

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Exploring the assumptions underlying genetic variation in host nematode resistance (Open Access publication)

Genet.Sel.Evol.40(2008)241–264 c INRA,EDPSciences,2008 DOI:10.1051/gse:2008001 Availableonlineat: Originalarticle Exploringtheassumptionsunderlying geneticvariationinhost nematoderesistance (OpenAccesspublication) AndreaBeateDoeschl-Wilson1?,DimitriosVagenas2, IliasKyriazakis2,3,StephenChristopherBishop 4 1 SustainableLivestockSystems,ScottishAgriculturalCollege,WestMainsRoad, Edinburgh,EH93JG,UK 2 AnimalHealthandNutritionDepartment,ScottishAgriculturalCollege,WestMainsRoad, Edinburgh,EH93JG,UK 3 FacultyofVeterinaryMedicine,UniversityofThessaly,Trikalon224, 43100,Karditsa,Greece 4 RoslinInstituteandRoyal(Dick)SchoolofVeterinaryStudiesRoslinBioCentre, MidlothianEH259PS,UK (Received18July2007;accepted21December2007) Abstract – The wide range of genetic parameter estimates for production traits and nema- tode resistancein sheep obtained from ?eldstudies gives risetomuch speculation. Using a mathematicalmodeldescribinghost–parasiteinteractionsinageneticallyheterogeneouslamb population,weinvestigatedtheconsequence of:(i)geneticrelationshipsbetweenunderlying growthandimmunologicaltraitsonestimatedgeneticparametersforperformanceandnema- toderesistance,and(ii)alterationsinresourceallocationontheseparameterestimates.Altering geneticcorrelationsbetweenunderlyinggrowthandimmunologicaltraitshadlargeimpactson estimatedgeneticparametersforproductionandresistancetraits.Extremeparametervaluesob- servedfrom?eldstudiescouldonlybereproducedbyassuminggeneticrelationshipsbetween theunderlyinginputtraits.Alteringpreferencesintheresourceallocationhadlesspronounced e?ects on the genetic parameters for the same traits. E?ects were stronger when allocation shiftedtowardsgrowth,inwhichcasewormburdenandfaecaleggcountsincreasedandge- neticcorrelationsbetweentheseresistancetraitsandbodyweightbecamestronger.Ourstudy hasimplicationsforthebiologicalinterpretationof?elddata,andforthepredictionofselec- tionresponsefrombreedingfornematoderesistance.Itdemonstratestheprofoundimpactthat moderateleve