Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis.docVIP

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Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis.doc

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Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis

Available online /content/6/4/363 Research Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis Mia Furebring1, Lena Douhan H?kansson2, Per Venge3, Bo Nilsson4 and Jan Sj?lin5 1Resident, Department of Medical Sciences, Section of Infectious Diseases, University Hospital of Uppsala, Sweden 2Associate Professor, Department of Medical Sciences, Section of Clinical Chemistry, University Hospital of Uppsala, Sweden 3Professor, Department of Medical Sciences, Section of Clinical Chemistry, University Hospital of Uppsala, Sweden 4Associate Professor, Department of Oncology, Radiology and Clinical Immunology, University Hospital of Uppsala, Sweden 5Associate Professor, Department of Medical Sciences, Section of Infectious Diseases, University Hospital of Uppsala, Sweden Correspondence: Mia Furebring, mia.furebring@medsci.uu.se Received: 21 November 2001 Revisions requested: 7 March 2002 Revisions received: 14 May 2002 Accepted: 16 May 2002 Critical Care 2002, 6:363-370 This article is online at /content/6/4/363 ? 2002 Furebring et al., licensee BioMed Central Ltd Published: 13 June 2002 (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Introduction Treatment of patients with severe sepsis with agents antagonising the effects of C5a has been proposed based on beneficial effects in animal experiments and in vitro studies demonstrating upregulation of the C5a receptor (CD88) on granulocytes by endotoxin. Materials and methods CD88 expression on leukocytes from 12 patients with severe sepsis or septic shock was analysed by flow cytometer, and serum complement factors C3a and C5b-9 were measured by enzyme immunoassay techniques. Results The granulocyte CD88 expression on day 1 was lowered (36; range, 2–59) in comparison with controls (63; range, 25–88) (P 0.001), despite complement activation, while the monocyte CD88 expression was unchanged. The receptor reduction correlated significantly to