Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel.docVIP

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Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel.doc

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Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel

BMC Clinical Pharmacology BioMedCentral Research article Open Access Expression of thymidine phosphorylase in peripheral blood cells of breast cancer patients is not increased by paclitaxel Rupert Bartsch, Guenther G Steger, Birgit Forstner, Catharina Wenzel, Ursula Pluschnig, Blanka Rizovski, Gabriela Altorjai, Christoph C Zielinski and Robert M Mader* Address: First Department of Medicine and Cancer Centre, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria Email: Rupert Bartsch - rupert.bartsch@meduniwien.ac.at; Guenther G Steger - guenther.steger@meduniwien.ac.at; Birgit Forstner - birgit.forstner@meduniwien.ac.at; Catharina Wenzel - catharina.wenzel@meduniwien.ac.at; Ursula Pluschnig - ursula.pluschnig@meduniwien.ac.at; Blanka Rizovski - blanka.rizovski@meduniwien.ac.at; Gabriela Altorjai - gabriela.altorjai@meduniwien.ac.at; Christoph C Zielinski - christoph.zielinski@meduniwien.ac.at; Robert M Mader* - robert.mader@meduniwien.ac.at * Corresponding author Published: 18 July 2007 Received: 6 March 2007 Accepted: 18 July 2007 BMC Clinical Pharmacology 2007, 7:7 doi:10.1186/1472-6904-7-7 This article is available from: /1472-6904/7/7 ? 2007 Bartsch et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: A synergistic cytotoxic effect has been hypothesized for taxanes and capecitabine, a prodrug of 5-fluorouracil. Based on preclinical studies, this synergism has been attributed to an up-regulation of the enzyme thymidine phosphorylase (TP). Beside tumour tissue, TP is highly expressed in white blood cells, possibly causing increased hematotoxicity, when taxanes are combined with capecitabine. So far, this hypothesis has not been investigated in hum