Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cells.docVIP

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Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cells.doc

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Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cells

Annals of Surgical Innovation and Research BioMedCentral Research article Open Access Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cells Kerstin Reimers*?1, Christine Radtke?1, Claudia Y Choi?1, Christina Allmeling1, Susanne Kall1, Paul Kiefer2, Thomas Muehlberger1 and Peter M Vogt1 Address: 1Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover Podbielskistra?e 380, 30659 Hannover, Germany and 2University Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany Email: Kerstin Reimers* - reimers.kerstin@mh-hannover.de; Christine Radtke - radtke.christine@mh-hannover.de; Claudia Y Choi - choi.claudia@mh-hannover.de; Christina Allmeling - allmeling.christina@mh-hannover.de; Susanne Kall - kall.susanne@mh- hannover.de; Paul Kiefer - Paul.Kiefer@uni-duesseldorf.de; Thomas Muehlberger - muehlberger.thomas@mh-hannover.de; Peter M Vogt - vogt.peter@mh-hannover.de * Corresponding author ?Equal contributors Published: 19 November 2009 Received: 25 July 2009 Accepted: 19 November 2009 Annals of Surgical Innovation and Research 2009, 3:13 doi:10.1186/1750-1164-3-13 This article is available from: /content/3/1/13 ? 2009 Reimers et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The objective of the present study was to evaluate the aptitude of TRAIL gene expression for inducing apoptosis in co-cultivated T-cells. This should allow preparing a strategy for the development of a durable, allogenic skin substitute based on the induction of an immune-privileged transplant. In order to counteract the significant potential of rejection in transplanted allogenic keratinocytes, we created a murine k