Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls A substudy of the Multicenter AIDS Cohort Study.docVIP

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Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls A substudy of the Multicenter AIDS Cohort Study.doc

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Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls A substudy of the Multicenter AIDS Cohort Study

AIDS Research and Therapy BioMedCentral Research Open Access Fat distribution and longitudinal anthropometric changes in HIV-infected men with and without clinical evidence of lipodystrophy and HIV-uninfected controls: A substudy of the Multicenter AIDS Cohort Study Todd T Brown*1, Xiaoqiang Xu1, Majnu John2, Jaya Singh3, Lawrence A Kingsley4, Frank J Palella5, Mallory D Witt6, Joseph B Margolick1 and Adrian S Dobs1 Address: 1Johns Hopkins University, Baltimore, MD, USA, 2Childrens Hospital of Philadelphia, Philadelphia, PA, USA, 3Saint Clares Hospital, Dover, NJ, USA, 4University of Pittsburgh, Pittsburgh, PA, USA, 5Northwestern University Feinberg School of Medicine, Chicago, IL, USA and 6David Geffen School of Medicine at UCLA and Harbor-UCLA Medical Center, Los Angeles, CA, USA Email: Todd T Brown* - tbrown27@; Xiaoqiang Xu - stevenxu@; Majnu John - majnujohn@; Jaya Singh - drjayasingh@; Lawrence A Kingsley - kingsley@; Frank J Palella - f-palella@; Mallory D Witt - mwitt@; Joseph B Margolick - jmargoli@; Adrian S Dobs - adobs@ * Corresponding author Published: 13 May 2009 Received: 2 May 2008 Accepted: 13 May 2009 AIDS Research and Therapy 2009, 6:8 doi:10.1186/174 2-64 05-6-8 This article is available from: /content/6/1/8 ? 2009 Brown et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Fat abnormalities are common among HIV-infected persons, but few studies have compared regional body fat distribution, including visceral fat, in HIV-infected and HIV-uninfected persons and their subsequent trajectories in body composition over time. Methods: Between 1999 and 2002, 33 men with clinical evidence of lipodystrophy (LIPO+), 23 HIV-infected men without clinical evidence of lipodytr