Genome position and gene amplification.docVIP

Open Access Re rch 2007GajduskovaetVoal.lumesea8, Issue 6, Article R120 Genome position and gene amplification Pavla Gajduskova*?, Antoine M Snijders*, Serena Kwek*, Ritu Roydasgupta?, Jane Fridlyand??, Taku Tokuyasu?, Daniel Pinkel?§ and Donna G Albertson*?§ Addresses: *Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143-0808, USA. ?Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143-0808, USA. ?Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143-0808, USA. §Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143-0808, USA. ?Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská, Brno, 612 65, Czech Republic. Correspondence: Donna G Albertson. Email: albertson@ Published: 21 June 2007 Received: 6 November 2006 Revised: 15 May 2007 Accepted: 21 June 2007 Genome Biology 2007, 8:R120 (doi:10.1186/gb-2007-8-6-r120) The electronic version of this article is the complete one and can be found online at /2007/8/6/R120 ? 2007 Gajduskova et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. GenesiptyfGoamplificationernaodmruicga-rneasliysstineasntumorsofcehumangene tocellsampexpressinglify in humadihydrofolaten cells. /preductase provide insight into the effects of genome position on the propen- Abstract Background: Amplifications, regions of focal high-level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however, the use of amplification as a mechanism for overexpression