静脉持续滴注氟尿嘧啶联合顺铂治疗晚期头颈部鳞癌30例的临床分析.pdfVIP

.378. 实用癌症杂志双脚撞在7 月第24 卷第4 期 ηM 阶毗tical J回l.11l4I of Cancer. July 汉阴.Vol24 ， N队4 静脉持续滴注氟尿略脏联合顺锦治疗晚期头颈部鳞癌 30 例的临床分析 陈玉芳常建华 [摘要} 回的探讨持续静脉满泣..尿嗦唆联合顺铃，治疗复发和远处转移头颈部鳞癌的疗效和安全性。方法 2 2 30 例复发和转移头颈部痴予5-Fu 750 mgI( m • d) 持续静脉滴注 120 h ，每天 DDP 25 mglm ， 第 1 问 3 天，3W 为 1 个周期， 2 个周期后许价疗效。结巢 CR 1 例，PR 12 例，近期客观有效率为 44.8% (13/29) 。中位叽p 7. 8 个月。初治与集治 有效率分别为76.9% ( 10/13)、 18.7%(3/1的，差异有统计学意义(χ2 =9.814 ,P=0.02 0.05) 。主要不良反应为骨髓 抑制，胃肠道反应和和膜炎。结论持续静脉滴泳氟尿喀咬联合顺钧治疗晚期头颈部癌安全有效。 I 关键词} 氟且在嗜咬;化疗;头颈部鳞癌 中朋分类号:民739.91 )c献标识码:A 文章编号:1∞1-5930(2侃到~) 04-0378-03 Analysis of Chemotherapy with 5-Fu by Con仙lOUS Intravenous Infusion Combind with Cisplatin in Patients with Advanced Squamous Cell Carcinoma of the Head and Neck CHEN YU作咽， CHANG Jian唰hoo. Yan阱ou No.l Peop削Hospita1 , Yangz恤，225侧 (A加tractJ Objective To investig脚加effic町 and toxicities of 5仇 by continuous intravenous infusion combined with ci自platin( 仰的 in the 111棚阳ent of 附UJTent 皿d metasta加hωd and neck 叫阳mous cell carcinoma of 由e efficacy and safe- 2 ty.Me伽例如 30ω酬阳也附UJTent and metastatic head and neck cancer were treated by 5-Fu 750 mg / (m • d) by 120 hours continuous intravenous i曲lSion and DDP 25 mglm2 ,from dlω d3.四e chemother租py w创陀peated every 3 weeks. The efficacy and 协茸icities were reviewed after two cycles. Results 1 patient achieved complete 阳阳lse( CR) and 12 pa加nts had 阳rtialr萨 spon附(PR) ,80 the objective respouse rate( RR) w翩44.8% (13/29). Median time to pro阱自由ion( nî啊P)was7.8 mon阳. The response rate for 恤atment naive and t