不同亚胺培南输注时间治疗严重病原菌感染患者的疗效和安全性比较.pdfVIP

2 0 1 5 年 1 2 月 第 5 卷 第 2 3 期 ·临床研究· 不同亚胺培南输注时间治疗严重病原菌 感染患者的疗效和安全性比较 董振岭 广州市戒毒管理局医院，广东广州 510000 [ 摘要 ] 目的 探析病原菌严重感染病人进行亚胺培南不同输注时间疗法的临床效果及安全性比较。 方法 对我院 2013 年 9 月～ 2014 年 6 月病原菌严重感染患者 100 例，根据随机数字表法分为研究组、对照组，每 组 50 例，研究组进行亚胺培南延长输注疗法，对照组进行亚胺培南常规疗法，比较两组的临床效果；比较两 组的不良反应发生情况。 结果 研究组的临床有效率为 86.0%，显著高于对照组的 56.0%，差异有统计学意 义（P ＜ 0.05）；研究组发生皮疹、消化道不适、丙氨酸氨基转移酶升高等不良反应情况与对照组比较，差异 无统计学意义（P ＞ 0.05）。 结论 病原菌严重感染患者进行亚胺培南延长输注疗法，临床效果确切，可靠安 全，值得临床推广。 [ 关键词 ] 临床观察；病原菌感染；亚胺培南；输注时间 [ 中图分类号 ] R459.7 [ 文献标识码 ] B [ 文章编号 ] 2095-0616（2015）23-199-03 Comparison of curative effects and safety of different infusion time of imipenem in treatment of patients with severe pathogenic bacteria infection DONG Zhenling Guangzhou Drug Administration Hospital of Guangdong Province,Guangzhou 510000,China [Abstract] Objective To explore the comparison of clinical curative effects and safety of different infusion time of imipenem in treatment of patients with severe pathogenic bacteria infection. Methods 100 patients with severe pathogenic bacteria infection who were admitted to our hospital from September 2013 to June 2014 were randomly allocated to the research group and the control group according to random digital table method,with 50 in each. The research group was received treatment of prolonged infusion of imipenem while the control group was received routine treatment of imipenem.Clinical curative effect and occurrence of adverse reactions of two groups were compared. Results Clinical effective rate of the research group was 86.0%,significantly higher than that of the control group 56.0%.The difference had statistical significance (P ＜ 0.05).Occur