-耳内耳聋生物学治疗的挑战与实践杨仕明20110806.ppt

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-耳内耳聋生物学治疗的挑战与实践杨仕明20110806.ppt

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-耳内耳聋生物学治疗的挑战与实践杨仕明20110806

Delivery of polyplex to cochlea in vivo Polyplex was delivered to cochlea by a micro-invasive surgery. Gelfoam? soaked with polyplex was placed in the round window niche and directly contact round window membrane. 季胺化壳聚糖-β环糊精（CM-β-CD）载基因（Math1）纳米粒基因传递系统的构建 Ren LL, et al. Math1 gene transfer based on the delivery system of quaternized chitosan/ Na- carboxymethyl-β- cyclodextrin nanoparticles. J Nanosci Nanotec 2010.10(11): 7262-7265 （国家发明专利申请号200910237305.3）季胺化壳聚糖-β环糊精（CM-β-CD）载基因（Math1）纳米粒基因传递系统的构建 Ren LL, et al. Math1 gene transfer based on the delivery system of quaternized chitosan/ Na- carboxymethyl-β- cyclodextrin nanoparticles. J Nanosci Nanotec 2010.10(11): 7262-7265 （国家发明专利申请号200910237305.3） Wu N, Ren LL, Zhao LD, Guo WW, Liu HZ, Yang SM*. Gene delivery to sensory cells in the adult murine cochlea by activated polyamidoamine dendrimers/ cyclodextrin nanoparticles with low toxicity and high efficacy. Nano Lett 2011(submitted).）（国家发明专利申请号201110005066.6） PAMAM树状大分子-环糊精（CMAP）载基因（Math1）纳米粒基因传递系统的构建 PAMAM树状大分子-环糊精（CMAP）载基因（Math1）纳米粒基因传递系统的构建 Wu N, Ren LL, Zhao LD, Guo WW, Liu HZ, Yang SM*. Gene delivery to sensory cells in the adult murine cochlea by activated polyamidoamine dendrimers/ cyclodextrin nanoparticles with low toxicity and high efficacy. Nano Lett 2011(submitted).）（国家发明专利申请号201110005066.6）耳聋基因治疗的局限性分子治疗？内耳基因治疗与小分子治疗相结合的新策略 Yang SM, et al, Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats. Plos One 2011, accepted Yang SM, et al, Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats. Plos One 2011, accepted Math1基因联合小分子DAPT Yang SM, et al, Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats. Plos One 2011, accepted Yang SM, et al, Effects of DAPT and Atoh1 Overexpression on Ha