溃疡性结肠炎两种治疗方案的临床比较.docVIP

溃疡性结肠炎两种治疗方案的临床比较 作者：计为明 徐永正 陆志芳 【摘要】 　　目的探索高效安全价廉适宜基层 医院 推广的 治疗 溃疡性结肠炎(“溃结”)的方案，采用在常规治疗基础上加用自制“溃结合剂”灌肠。 方法 对经大肠镜检查确诊的77例“溃结”者，随机分治疗组38例给予常规治疗（但不用激素）基础上加用“溃结合剂”1号2号方灌肠;对照组39例采用常规治疗，9例并加用激素，疗程均为4周，治疗结束后复查肠镜和评定疗效。结果治疗组36例、对照组35例完成疗程和观察，有效率分别为97.2%和91.4%，差异无显著性（P0.05），但痊愈和显效率两组差异有非常显著性（91.6%：62.9%）（P0.01），治疗组毒副反应少而轻（3/36：10/35）,医疗费亦比对照组低。结论对 “溃结”患者尤其中轻型者加用“溃结合剂”灌肠，疗效优于常规对照组，且由于使用方便、顺应性强、毒副反应少、价格低廉，而适宜在基层医院推广 应用 。 【关键词】 中西医结合 溃疡性结肠炎 溃结合剂 【Abstract】ObjectiveTo explore the effective,cheap,safe remedy for ulcerative colotis,fit to be applied in the basic unit hospital,use the self-made “ulcerative colitis” mixture clyster based on the conventional treatment.MethodsStochastically divided the 77 patients diagnosed ulcerative colitis by colonoscopy into two groups,one group of 38 patients are give a clyster with the mixture of no-1 and no-2 based on the conventional therapy except hormone,another group of 39 patients as the control group take the conventional therapy and hormone,both of the courses last four weeks.ResultsWe have completed 71 cases in the trial (group therapy 36 cases vs group control 35 cases) ,the effectiveness respectively is 97.2% and 91.4%,does not have the significant difference(P0.05),but the recovery rate and effect are quite different,the treatment group is high(91.6%;62.9% P0.01).the poisonous side reaction is few and light(3/36:10/35).ConclusionAdded the ulcerative colitis mixture clyster to slight ulcerative colitis patients, the curative effect is better than the conventional control groups, meanwhile, it is easy to operate, compatible, few poisonous, cheaper price, suitable for the basic unit hospital to applied and use. 【Key words】integrated traditional and western medicine；ulcerative colitis;ulcerative colotis mixture 以往认为溃疡性结肠炎北欧和北美发病率高，可达2~10/10万，而国内1986年12家医院10~20年内仅收治581例［1］，但1987~1993年报告2137例，其患病率增加明显［2］。 目前 ，由于肠镜检查普遍，基层医院确诊本病者亦日见增多。溃疡性结肠炎的病因复杂，肠道微生物、肠上皮细胞、宿主免疫系统的相互作用还不完全清楚，其重要的 影响 因素包括饮食、微生物抗原、血管内皮细胞、神经免疫系统、脑肠神经肽和各种调节肠道功能及免疫反应的宿主基