老年糖尿病病人PAF表达、TXB2及6-K-PGF1α活性改变的临床研究.docVIP

老年糖尿病病人PAF表达、TXB2及6-K-PGF1α活性改变的临床研究 老年糖尿病病人PAF表达、TXB2及6-K-PGF1活性改变的临床研究 　摘 要 目的：探讨老年糖尿病人血小板活化因子（PAF）表达、血栓素B2（TXB2）、6-酮-前列腺素F1（6-K-PGF1）水平改变的临床意义。方法：住院的老年糖尿病病人98例（男、女各49例），分成无慢性血管性并发症组（A组49例）、有慢性血论文联盟Www.LW管性并发症组（B组49例），对照组（C组50例）。分别观测血中PAF表达、TXB2及6-K-PGF1水平的改变。结果：与对照组相比，老年糖尿病病人的血浆PAF表达、TXB2及6-K-PGF1水平明显升高。有慢性血管性并发症老年糖尿病病人较无并发症病人升高更明显。结论：老年糖尿病病人存在PAF、TXB2及6-K-PGF1水平明显升高，其中有慢性血管性并发症病人升高更明显。 　　关键词 老年糖尿病 PAF TXB2 6-K-PGF1 　　中图分类号：R587.1 文献标识码：B 文章编号：1006-1533(2012)05-0026-03 　　Clinical study on expression of platelet activating factor (PAF) 　　and changes of activities of TXB2 and 6-K-PGF1 in patients with senile diabetes 　　WANG De-zhong1 , WANG Gang2 , CHEN Yan1 　　（1. The People`s Central Hospital of Tengzhu City, Tengzhou, 277500; 2. Hongxu Health Center of Tengzhou City, Tengzhou, 277500） 　　ABSTRACT Objective: To observe the clinical significance of the expression of platelet activating factor (PAF) and activity changes of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 (6-K-PGF1) in patients with senile diabetes mellitus. Methods: 98 hospitalized cases (male and female 49 each) with senile diabetes mellitus were selected and divided into two groups (group A, without chronic vascular complications and group B, with chronic vascular complications).Control group was also designed. The expression of platelet activating factor (PAF) in blood, and the activity of thromboxane B2 (TXB2), 6-keto-prostaglandin F1 (6-K-PGF1) were determined. Results: Compared with those of control group, the expression of PAF, the activities of TXB2 and 6-K-PGF1 in plasma were all raised obviously in patients with senile diabetes mellitus. The results of group B were more obvious than those of group A. Conclusion: There were obvious increases in the expression of PAF , the activities of TXB2 and 6-K-PGF1in patients with senile diabetes mellitus, which were more obvious in patients with chronic vascular complications. 　　KEY WORDS senile diabetes mellitus; platelet activating factor