02 处方设计幻灯片.pptVIP

O N O H O O O Cl O O O N N O Cl N N Cl Cl F3C N OH griseofulvin cinnarizine halofantrine diazepam danazol Poorly water-soluble compounds Physico-chemical descriptors of some poorly water-soluble compounds MP Solubility at 37 °C, pH 7.5 Drug °C MW pKa log P Aqueous Fasted Fed Griseofulvin 220 352.8 n/a 2.2 14.6 18.4 38.8 Diazepam 125 284.7 3.4 2.9 59.7 115.6 318 Danazol 226 337.5 n/a 4.5 0.8 8